er að koma:
(Vond þýðing á meginefni:
"Timothy Sheahan frá háskólanum í Norður-Karólínu, annar af höfundum verksins, sagði í fréttatilkynningu að „á venjulegum tímum væru prófanir í venjulegum mönnum ekki augljóst næsta skref á leiðinni til prófana á mönnum. Þar sem þetta eru ekki á venjulegum tímum var hægt að sleppa þessu og meta það með samtímanotkun og koma á klínískum rannsóknum hjá fólki. Markmiðið er að ráðast beint á vírusinn, draga úr einkennum, minnka sjúkdómsvaldandi sjúkdóma og bjarga mannslífum. “
„Coronaviruses (CoVs) ferðast oft á milli tegunda sem leiða til nýlegra sjúkdómsútbrota, síðast sýnd með nýstofnaðri SARS-CoV-2, orsakavaldi COVID-19.
Hérna sýnum við að ríbónúkleósíð hliðstæða β-D-N4-hýdroxýcytidín (NHC, EIDD-1931) hefur breiðvirka veirueyðandi virkni gegn SARS-CoV-2, MERS-CoV, SARS-CoV og tengdum dýrarannsóknarhópi 2b eða 2c Bat -CoVs, auk aukins styrkleika gegn kórónuveiru sem hefur ónæmisbreytingar gagnvart núkleósíð hliðstæða hemlinum remdesivir.")
"NHC is highly active against SARS-CoV-2, MERS-CoV, and SARS-CoV in primary human airway epithelial cell cultures. (A) HAE were infected at an MOI of 0.5 with clinical isolate SARS-CoV-2 for 2 hours in the presence of NHC in duplicate after which virus was removed and cultures were washed in incubated in NHC for 48 hours when apical washes were collected for virus titration by plaque assay."
"NHC potently inhibits MERS-CoV and newly emerging SARS-CoV-2 replication"
"Researchers from Emory University in Atlanta; the University of North Carolina at Chapel Hill; and Vanderbilt University Medical Center in Nashville, Tenn., first tested EIDD-2801 in cells cultured in the laboratory. When those tests were encouraging, they gave the drug to mice that had been infected with coronaviruses that cause either SARS or MERS, and showed that it reduced the amount of virus in their bodies. In addition, the mice gained weight, another good sign.
The researchers say they were unable to test EIDD-2801 in mice infected with the virus that causes COVID-19 because right now most mice are not susceptible to infection with that virus.
A paper describing the new results appeared online today in the journal Science Translational Medicine.
Vanderbilt University Medical Center virologist Mark Denison, one of paper's authors, says there's already been a lot of research on other coronaviruses, so he's not worried that testing the drugs in animals will turn up any problems.
Timothy Sheahan of the University of North Carolina, another one of the paper's authors, said in a press release that "in normal times, testing in non-human primates would be the obvious next step on the road to human testing. Since these are not normal times, this could be skipped and evaluated under compassionate use and established clinical trials in people. The goal is to directly attack the virus, lessen symptoms, decrease pathogenesis and save lives."
"Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, the causative agent of COVID-19.
Herein, we show that the ribonucleoside analog β-D-N4-hydroxycytidine (NHC, EIDD-1931) has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir.
In mice infected with SARS-CoV or MERS-CoV, both prophylactic and therapeutic administration of EIDD-2801, an orally bioavailable NHC-prodrug (β-D-N4-hydroxycytidine-5′-isopropyl ester), improved pulmonary function, and reduced virus titer and body weight loss. Decreased MERS-CoV yields in vitro and in vivo were associated with increased transition mutation frequency in viral but not host cell RNA, supporting a mechanism of lethal mutagenesis in CoV.
The potency of NHC/EIDD-2801 against multiple coronaviruses and oral bioavailability highlight its potential utility as an effective antiviral against SARS-CoV-2 and other future zoonotic coronaviruses."
Hugsið ykkur ef þetta er rétt þá er hægt að gefa vírusnum inn eitur með pillum þannig að hann nái ekki að kopéra sig í líkamanum og lungunum.
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